Ashwell Prince was finally prised out by England at Headingley - after rewriting South Africa's history books.
Prince marked the 27th anniversary of Ian Botham's famous Ashes 149 on the same ground, with a replica score, having shared a new record fifth-wicket record stand against England with AB de Villiers (119 not out).
The pair shared 212 before debutant Darren Pattinson made Prince his second Test victim.
England also accounted for Mark Boucher and Morne Morkel in the afternoon session as the South Africans progressed to 427 for seven midway through the third day - a lead of 224 runs.
Boucher, dropped twice on eight, hauled a pull into his stumps off James Anderson and Morne Morkel was bowled through the gate by left-arm spinner Monty Panesar.
But npower series momentum remains with the tourists thanks to hundreds from their middle-order men.
De Villiers celebrated three figures shortly before lunch when, after being stuck on 99 for 13 balls, he dropped a single into the off-side off the bowling of Andrew Flintoff.
England certainly beat the bat with greater regularity this morning than they managed yesterday but had to wait for Australian-raised Pattinson's introduction for the first success for 75 overs.
Pattinson - again the last member of England's four-strong seam attack to be used by Michael Vaughan - got one to keep its line from round the wicket and have left-hander Prince caught behind.
Before then, De Villiers forced a four past cover in Stuart Broad's first over of the day, to take him and Prince beyond South Africa's previous best for the fifth wicket against England - Gary Kirsten and Mark Boucher's 192 at Durban in 1999.
Prince needed 13 deliveries to add to his overnight 134 but eventually reached his Test best, and brought up the 200 stand for good measure, with a cover-drive on the up for four off Broad.
All-rounder Flintoff did create the chance for a sixth wicket before the interval but Alastair Cook spurned a low opportunity at second slip to afford Mark Boucher an initial life.
He also escaped after lunch when Pattinson failed to cling on one-handed to a chance in his follow-through.