The Manchester United defender picked up the problem in the Old Trafford side's 3-2 defeat at Highbury. The injury forded 22-year-old Neville to sit out Monday's first training session at the England squad's Bisham Abbey headquarters.
Hoddle had been hoping that Neville would recover in time to be available for the Wembley encounter with the West African side. But Neville was reluctantly packing his bags and heading back to Manchester for treatment last night, alongside his Old Trafford team-mate Teddy Sheringham.
Neville joins knee victim Sheringham, his United colleague Gary Pallister (back) and the Arsenal defender Tony Adams (ankle) in dropping out of the 25-man squad Hoddle named last Friday.