Inter, under new coach Marcello Lippi, lost to an injury-time goal by Fernando Morientes. The Italians featured their world record signing Christian Vieri in attack but were without Ronaldo, resting after the Copa America.
McManaman was brought down after a run from which Inter goalkeeper Fabrizio Ferron could only parry Bosnian Elvir Bolic's free-kick. Raul followed up to score.
Lyon, who have spent pounds 27.5m building a side for the Champions' League, suffered a 2-1 home defeat by Montpellier in their opening match of the French season on Saturday. Lyon were without record signing Sonny Anderson, who has just recovered from injury.
The award to Franz Beckenbauer of German Player of the Century following a poll run by German television and a football magazine provided a reminder of happier times following the national side's 2-0 defeat to the United States in the Conferations' Cup on Friday. "The world is laughing at German football now," reported the Welt am Sonntag.