Wilkins' second goal of the season ended a five-year spell in which Brighton have failed to progress beyond the first round of a competition originally known as the League Cup, and the tie will give his side the chance to alleviate the unpleasant memories of 1983, when United beat them 4-0 in the FA Cup final replay.
Steve Foster, recently returned to the Goldstone Ground, will have particularly cause to anticipate next month's tie - he was suspended for the first game in 1983, before coming back to captain Brighton in the replay.
Scarborough meet Coventry City, early leaders in the Premier League until last night, as reward for their 5-3 victory at Bradford City last night (8-3 on aggregate).
Queen's Park Rangers, who took over at the top with their 1-0 win at Coventry, will face First Division Grimsby, while the Brentford manager, Phil Holder, takes his side back to his former club, Tottenham, in another London derby.
The one other London derby takes Millwall - 3-0 winners over Leyton Orient last night (5-2 on aggregate) - to Arsenal, while Chelsea take on Third Division Walsall.
Sheffield Wednesday will meet Hartlepool, 11th in the Third Division last season, and the League champions, Leeds United, are paired with Scunthorpe in a reprise of last season's second-round tie, when they were held to a 0-0 draw at Glanford Park before winning
3-0 at Elland Road.
Perhaps the outstanding tie of the round is the North-east derby between Newcastle and Middlesbrough, Kevin Keegan's side forcing a goalless draw at Mansfield Town on Tuesday night for a 2-1 aggregate win.
Manchester City take on Bristol City in what will be a chance for Keith Curle to demonstrate to one of his early clubs how far he has come. The England defender left Ashton Gate for Reading in 1987.
The Aston Villa manager, Ron Atkinson, travels back to Oxford United, where he was a bustling wing-half during their early Football League days. Kenny Dalglish takes Blackburn Rovers to Huddersfield Town, who went through on away goals last night after losing 1-0 at home to Sunderland.Reuse content