Athletic Bilbao, conquerors of Manchester United, will face German side Schalke in the quarter-finals of the Europa League.
Sporting Lisbon, who held off Manchester City to clinch their place in the last eight, will play Ukrainian side Metalist Kharkiv.
Bilbao and Sporting could face each other in the semi-finals - their quarter-finals have been paired together.
Two other Spanish sides are also still in the Europa League - Atletico Madrid play German club Hannover in one quarter-final with the winners facing the victors of the other between Dutch side AZ Alkmaar and Valencia.
EUROPA LEAGUE QUARTER-FINAL DRAW:
AZ Alkmaar v Valencia
Schalke v Athletic Bilbao
Sporting Lisbon v Metalist Kharkiv
Atletico Madrid v Hannover
::First legs to be played on March 29. Second legs to be played on April 5.
Atletico Madrid/Hannover v AZ Alkmaar v Valencia
Sporting Lisbon/Metalist Kharkiv v Schalke/Athletic Bilbao
::First legs to be played on April 19. Second legs to be played on April 26.