A dispiriting Champions League campaign means that City have travelled to Germany aware that progress from their group is impossible.
However, the Premier League champions can still qualify for the Europa League by finishing third. To do that they'll need to better the result of Ajax, who play Real Madrid.
It'll be a tall order to beat the German champions, who were denied a deserved victory at the Etihad back in October by a late Mario Balotelli equaliser. The Germans are undefeated in seven domestic games.
KICK-OFF: Tuesday, 7.45pm
Manchester City 1 (Balotelli) Borussia Dortmund 1 (Reus), Champions League, group phase, October 2012
When City have scored first in the Champions League this season they have lost, when they have conceded first they have drawn the game.
From the 85th minute of games onwards Dortmund have conceded six goals in their last seven Champions League matches, netting two in the meantime themselves.
Dortmund have never lost a Uefa competition match against an English side on home soil (W3 D3 L0).
Manchester City have won just one of their last five European trips to Germany.
Dortmund have made more defensive clearances than any other team in the Champions League (248).
Borussia Dortmund to win: 2
Manchester City to win: 3.5
TV: Live on Sky Sports 2 at 7.45pm