Porto are the firm favourites in this match-up, and will hope to take an unassailable lead to Spain for the second-leg.
But don't expect any goals of the season from Mourinho's old team - the Portuguese champions haven't scored from outside the box in this season's tournament.
Malaga boast three Hispanic favourites in the twilight of their careers: Javier Saviola; Roque Santa Cruz; and Joaquin (combined age of 93,) though the chances of all three getting a start tonight are slim.
Malaga's highly-coveted top scorer Isco is in good form domestically, having scored four in his last four games. Eliseu and Jackson Martinez are Malaga's and Porto's top Champions League scorers respectively, both tied on three.
PAST TWO MEETINGS...
Teams have never played before
Porto are unbeaten in their last 19 home games
They have only lost one game in any competition all season. That was a 2-1 defeat away to Paris St Germain in the group stage
Malaga have scored in 13 of their last 14 games
They kept clean sheets in their first five Champions League games this season, but have conceded five in the three since
They remain unbeaten in the competition
Porto to win: 1.84
Malaga to win: 5.2
TV: Live on Sky Sports 2 at 7.45pm