Brendan Rodgers has made two changes to the team that drew 2-2 with Everton in the Merseyside derby at the weekend.
Surprisingly, the Liverpool manager has elected to drop £23m Adam Lallana, with Philippe Coutinho coming into the side, while 20-year-old Lazar Markovic keeps his place.
Lallana, who has suffered a bit of injury trouble since moving to Anfield, is yet to replicate his Southampton form and is still searching for his first Liverpool goal.
The other change sees experienced left-back Jose Enrique replace Alberto Moreno, who too has had a difficult start to his Liverpool career.
For Basel, Paolo Sousa has made three changes after watching his top of the table team draw 1-1 with Thun.
Fabian Frei, Ahmed Hamoudi and 17-year-old forward Breel Embolo will start at St Jakob-Park.
LINE-UPS:
FC Basel: Vaclik, Schär, Suchy, Safari, Serey Die, Frei, Hamoudi, El Nenny, Xhaka, Streller, Embolo.
Subs: Vailati, Zuffi, Delgado, Kakitani, Calla, Gashi, Gonzalez.
Liverpool: Mignolet, Manquillo, Skrtel, Lovren, Enrique, Gerrard, Henderson, Coutinho,Sterling, Markovic,Balotelli
Subs: Jones, Toure, Moreno, Lucas, Lallana, Lambert, Borini
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