Brendan Rodgers has made just one change to the Liverpool team that was beaten 1-0 to Aston Villa at Anfield on Saturday.
Teenage sensation Raheem Sterling will start in place of Lazar Markovic, who struggled in his first start for the club.
Adam Lallana will make his European debut, while Mario Balotelli continues up front despite his struggles against Nathan Baker and Philippe Senderos.
Markovic is suspended so does not make the bench, with Suso replacing him among the substititues. Rickie Lambert will also make his European bow should he play.
Liverpool: Mignolet, Manquillo, Moreno, Lovren, Sakho, Gerrard, Henderson, Coutinho, Sterling, Lallana, Balotelli.
Subs: Jones, Enrique, Toure, Lucas, Suso, Borini, Lambert.
Ludogorets: Borjan, Alek, Minev, Moti, Junior Caicara, Anicet Abel, Dyakov, Marcelinho, Aleksan, Bezjak, Misidjan.
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