Although these teams have never played each other the prospects of this tie seem promising as Plzen are unbeaten and have won four out of their last six as they lead the Czech Liga, whereas City have struggled for form so far only winning two out of their first four Premier League games.
The match represents the first chance for new City manager Manuel Pellegrini to see if he can bring the magic touch he showed with Malaga in Europe last season.
Kick-off: Tuesday, 7:45
The sides have never met.
Plzen haven’t been goal shy at all this season, they’ve found the net 21 times already.
Plzen’s centre-back Marian Cisovsky scored an impressive five goals in the qualifying stages.
In 2011 they ended third in a group containing Barcelona and AC Milan.
City have never progressed past the group stage of the competition.
Plzen to win: 17.5
City to win: 8.11
TV: Live on Sky Sports 2 at 7:45. Highlights on ITV at 10:35.