Southampton travel to Oakwell following their last-gasp draw with Sunderland on Saturday and could hand a first start to record-signing Dani Osvaldo after a fiery substitute appearance from the Italian in the Premier League match. Barnsley will be without defender Jean Yves Mvoto through suspension but may hand a debut to new signing Paddy McCourt who joined the club last week.
The Tykes find themselves at the foot of the Championship after shipping 12 goals in their opening four games and will hope Luke Steele continues his League Cup heroics after saving three penalties in the shootout with Scunthorpe in the first round.
The two teams have met once before in the League Cup, Southampton triumphing with a 2-1 victory in 1997.
KICK-OFF: Tuesday, 7.45pm
PAST THREE MEETINGS…
Southampton 2 (Lallana 2) Barnsley 0, Championship, March 2012
Barnsley 0 Southampton 1 (Connolly), Championship, August 2011
Barnsley 0 Southampton 1 (McGoldrick), Championship, January 2009
In 56 meetings between the two teams, Southampton have won just one more game than Barnsley (22).
The Tykes goal difference of -8 is the worst in the Championship.
Southampton are unbeaten in their opening two Premier League fixtures.
Barnsley to win: 4.8
Southampton to win: 1.86
TV: Highlights on BBC1, Wednesday at 11.35pm.