Tonight will be the second time these two clubs have met in three days. Sunday’s game saw five goals, two red cards and a controversial incident concerning referee Mark Clattenberg - tonight has a lot to live up to.
Both teams will likely put their faith in younger players ahead of key weekend Premier League fixtures.
Chelsea will be without John Terry, Branislav Ivanovic and Fernando Torres due to suspension. Frank Lampard will miss out due to a shin injury which could keep him out till mid-November.
Rio Ferdinand, Robin van Persie and Wayne Rooney look set to be rested after last weekend’s hectic fixture. Shinji Kagawa will be out for up to four weeks with a knee injury.
KICK-OFF: Tonight, 19:45
PAST THREE MEETINGS...
Chelsea 2 (Mata, Ramires) Manchester United 3 (Luiz OG, Van Persie, Hernandez) October 2012
Chelsea 3 (Evans OG, Mata, Luiz) Manchester United (Rooney x2, Hernandez)
Manchester United 3 (Smalling, Nani, Rooney) Chelsea 1 (Torres)
This is the fourth League Cup meeting between the sides.
Manchester United are unbeaten in last six games against Chelsea. Won 5 and drawn 1.
Van Persie, who is likely to be rested, has scored more goals at Stamford Bridge than any other visiting player in Premier League history with 6 goals.
Chelsea have failed to reach the quarter-finals in only 3 of the last 11 years.
Chelsea win – 2.16
Draw - 3.95
Manchester United win – 3.45
TV: Live on Sky Sports at 7.45pm. Highlights on BBC1 at 11.15pm.