Both teams sit in the top half of the league table with just one point separating them.
Mauricio Pochettino will be without injured defenders Eric Dier and Kyle Naughton for the fixture. Striker Emmanuel Adebayor has returned from Ghana where he was allowed a break for personal reasons but is not expected to feature.
KICK-OFF: Wednesday, 7.45pm
PAST THREE MEETINGS…
Tottenham 1 (Adebayor) Newcastle 2 (Ameobi, Pérez), Premier League, October 2014
Newcastle 0 Tottenham 4 (Adebayor 2, Paulinho, Chadli), Premier League, February 2014
Tottenham 0 Newcastle 1 (Remy), Premier League, November 2013
Newcastle haven’t reached the semi-final in the League Cup since 1976 – where they were eventual runners-up to Manchester City.
Newcastle have seen off two Premier League teams already in the competition this season – beating Crystal Palace and holders Manchester City to win a place in the quarter-finals.
Tottenham edge the head-to-head record between the two teams in recent years – winning 5 of the last 10 fixtures. Newcastle have won 3, with 2 draws.
Tottenham were victorious when they last faced Newcastle in the League Cup in 2008 – thanks to goals from Roman Pavlyuchenko and Jamie O’Hara
Tottenham to win: 1.80
Newcastle to win: 3.90
Tottenham 5 Newcastle 0 - Newcastle will hope that Spurs are not as ruthless as they were when Harry Redknapp’s men humiliated them 5-0 in 2012. Goals from Benoit Assou-Ekotto, Louis Saha, Niko Kranjčar and Emmanuel Adebayor sealed all three points at White Hart Lane.
TV: Highlights on BBC1 at 11.05pm.