Manchester United boss Sir Alex Ferguson is in search of his sixth FA Cup with the Reds and will welcome back Wayne Rooney to his squad as well as Nani for this Third Round replay .
Ferguson has also said that the injury sustained to captain Nemanja Vidic is not as bad as first feared, with the Serbian available for selection. Ashley Young is ruled out.
James Collins, West Ham's two-goal hero when the sides drew 2-2 at Upton Park, is ruled out having sustained a calf injury at the weekend against Sunderland.
The winner will play Fulham, who narrowly beat Blackpool last night.
KICK-OFF: Wednesday 8.05PM
PAST THREE MEETINGS...
West Ham 2 (Collins 2) Manchester United 2 (Cleverly, Van Persie), FA Cup, January 2013
Manchester United 1 (Van Persie) West Ham 0, Premier League, November 2012
West Ham 2 (Noble 2) Manchester United 4 (Rooney 3, Hernandez), Premier League, April 2011
Manchester United have won eight of their last 10 league and cup matches against West Ham.
West Ham have not won a match at Old Trafford since May 2007. Former Hammer and Red Devil Carlos Tevez scored the only goal of the match to ensure West Ham’s Premier League survival on the last day of the season.
West Ham have not won an away game since November 2012, beating Newcastle.
Manchester United boast the best record in the FA Cup, with 18 appearances in the final, 11 of which were won.
West Ham have been beaten on each of the last six occasions they have been drawn against Premier League clubs in the FA Cup.
The last time West Ham beat a Premier League side in the FA Cup, they went on to reach the final back in 2006. (Middlesbrough, Semi-final)
Manchester United: 1.36
West Ham: 10
TV: Live on ITV1, 8.05pm