Ronald Koeman has named a full-strength side for the fourth round match against Crystal Palace.
The Dutch coach has made just one change from the team that beat Newcastle last week, with Jack Cork coming back into midfield in place of teenager Harrison Reed.
That means the in-form trio of Eljero Elia, Dusan Tadic and Graziano Pelle start for the Saints.
Alan Pardew has made three changes to his side with goalkeeper Wayne Hennessey taking over from Julian Speroni, Frazier Campbell taking the place of Dwight Gayle and Marouane Chamakh in place of Jason Puncheon.
Southampton: Forster, Clyne, Fonte, Gardos, Bertrand, Cork, Ward-Prowse, Davis, Tadic, Elia, Pelle.
Subs: Davis , Long, Isgrove, Reed, McCarthy Targett, Seager.
Crystal Palace: Hennessey, Kelly, Delaney, Dann, Ward, Zaha, Ledley, McArthur, Campbell, Chamakh, Sanogo.
Subs: Speroni, Mariappa, Hangeland, Bannan, Puncheon, Gayle, Murray.Reuse content