Sunderland were eliminated from the FA Cup by third-tier Notts County on today while Cesc Fabregas' 90th-minute goal spared Arsenal from being dumped out by Leeds.
Notts County's 2-1 victory secured the biggest shock of the third round so far and allowed Paul Ince to prevail over former Manchester United teammate Steve Bruce, whose Sunderland side was sixth in the topflight.
There were two other Premier League casualties. Blackpool went down 2-0 at third-tier Southampton and West Bromwich lost 1-0 at Reading of the second-tier League Championship.
Leeds looked set to follow last season's victory over Manchester United by ousting Arsenal before Fabregas canceled out Robert Snodgrass' spot kick to earn a 1-1 draw.
"Leeds were well organized, they were quickly on us and maybe our game was not quick enough to get out of their pressure," said Arsenal manager Arsene Wenger, who made nine changes from the team which drew 0-0 with Manchester City
Stoke and Wolverhampton will also have to contest replays, but Premier League rivals Aston Villa, Birmingham, Blackpool, Bolton, Everton, Fulham, West Ham and Wigan all secured places in Sunday's fourth-round draw.
At the Stadium of Light, Craig Westcarr and Lee Hughes scored for Notts County before Darren Bent pulled one back from the penalty spot for Sunderland, which rested several first-team regulars.
West Brom's elimination came after Reading striker Shane Long netted before the Baggies had Jonas Olsson sent off for a second bookable offense.
Lee Barnard and Guly Do Prado got the goals for Southampton that sent a weakened Blackpool side out of the competition.
Wolves could not follow up their midweek league win over Chelsea at Doncaster.
Stephen Hunt's spot kick salvaged a draw for the visitors before having George Elokobi sent off for a challenge on James Coppinger.
Doncaster led 2-1 at halftime after Billy Sharp and James Hayter scored twice in as many minutes to cancel out Nenad Milijas' opener for Wolves.
Stoke also faces a replay after Tuncay Sanli canceled out Michael Chopra's goal for Cardiff to earn a 1-1 draw.
Goals from Kyle Walker, Marc Albrighton and Stiliyan Petrov clinched a 3-1 victory at Sheffield United for Aston Villa, which had Ashley Young sent off.
Kevin Davies and Johan Elmander netted in Bolton's 2-0 win against non-league York, Everton routed League Championship Scunthorpe 5-1 and Fulham crushed Peterborough 6-2, with Diomansy Kamara scoring a hat trick.
West Ham, which was bottom in the Premier League, beat Barnsley 2-0 thanks to goals from Jonathan Spector and Frederic Piquionne, Wigan edged Hull 3-2, Birmingham won 4-1 at Millwall, and Blackburn ousted League Championship leader Queens Park Rangers with a 1-0 win.