Hereford manager John Trewick has been sacked following a meeting with chairman Graham Turner.
The move comes with the Bulls 11 points clear of the relegation zone in Coca-Cola League Two.
Former boss Turner will take over as manager on a short-term basis before a decision is made on a long-term successor to Trewick.
A club statement read: "The club would like to place on record our thanks for the considerable hard work he (Trewick) has put into the club both as manager and coach."
Trewick also issued a statement on the club's official website, saying: "I was given the reasons behind the decision which I understand and accept.
"The most important thing to me is the continued Football League status of Hereford United. I have invested too much time at the club to see it jeopardised.
"I sincerely hope with Graham Turner taking over it instils the all-round belief that the club can finish in a more comfortable position."