Argentina will play a friendly international against Portugal in London on Feb. 9.
It will be the second time each side has played at Arsenal's Emirates Stadium. Argentina lost 3-0 to Brazil in September 2006, while Portugal beat the same opponent 2-0 five months later.
The match could feature the world's two best players in Argentina striker Lionel Messi and Portugal forward Cristiano Ronaldo.
Arsenal chief executive Ivan Gazidis says it "is a fantastic opportunity for football lovers in the UK to watch some of the world's best players."
Arsenal has hosted a total five internationals since its 60,355-seat stadium opened in July 2006.