Diego Forlan will start for Uruguay in place of the banned Luis Suarez in the World Cup second round clash against Colombia.
The 35-year-old will receive his 85th cap as Oscar Tabarez prepares his side to face Colombia without star striker Suarez.
Diego Godin, who scored the winner against Italy to send Uruguay through from Group D, starts at the back alongside Atletico Madrid youngster Jose Gimenez.
Nicolas Lodeiro drops out from the starting XI and is replaced by defensive midfielder Diego Perez.
Meanwhile, Colombia revert to their normal starting XI after resting the likes of Juan Cuadrado against Japan. Jackson Martinez retains his place in the team after his two goals inspired them to a 4-1 win.
Colombia: Ospina; Zuniga, Yepes, Zapata, Armero; Aguilar, Sanchez, J Rodriguez, Cuadrado; Gutierrez, Martinez
Uruguay: Muslera; Caceres, Godin, Gimenez, Pereira; Arevalo Rios, Perez, Gonzalez; Cavani, Forlan, C Rodriguez