It has been a whirlwind week of change and controversy for the English game, throwing the Football Association into a tailspin.
The governing body decided on Tuesday that Sam Allardyce's position was untenable after secretly-filmed footage emerged of the recently-appointed Three Lions boss making a string of controversial comments.
The Daily Telegraph's investigation brought an ignominious end to his reign after just one match and 67 days, with England Under-21s manager Southgate parachuted into the hotseat for the final four matches of 2016.
World Cup qualifiers at home to Malta and in Slovenia await in the coming fortnight, with Rashford set to be included when the 46-year-old announces his first squad on Sunday. His absence from Thursday's Young Lions squad all but confirmed his return.
An incredible breakthrough year has seen the striker become a mainstay for Manchester United and led to Roy Hodgson taking him to Euro 2016.
Rashford netted on his debut against Australia and made an impact in his two appearances from the bench in France, yet was omitted for Allardyce's first - and only - match in charge and dropped down to the Under-21s.
The 18-year-old fired a hat-trick in last month's 6-1 mauling of Norway, leading then Under-21s manager Southgate to say it would give the senior team boss "food for thought". This week's remarkable turn of events means it will be him making the call.
England manager contenders
England manager contenders
1/6 Gareth Southgate - 6/4
Highly thought of by the decision-makers at the Football Association, the former Middlesbrough boss was brought into the fold to coach the Under-21s with an eye on future progression. Faltered at last year's Under-21 European Championship but led the team to victory at the Toulon tournament in the summer. Had no interest in succeeding Hodgson but takes charge for England's next four matches against Malta, Slovenia, Scotland and Spain while the FA looks for a permanent appointment.
2/6 Steve Bruce - 2/1
The former Manchester United defender was interviewed in the summer about the vacant England manager's job. Just days after speaking to the FA, Bruce decided to call time on his spell at Hull, where he had become the most successful manager in the club's history. He remains out of work.
3/6 Eddie Howe - 8/1
A smart, erudite and tactically-savvy coach who, at 38, looks to have a bright future at the top of the game. The manager has flourished at Bournemouth and only last week described coaching England as the "ultimate" job. "I would never say no," Howe said.
4/6 Alan Pardew - 8/1
Seemed to be a new man after swapping Newcastle for Crystal Palace and some fine early-season results saw him seriously linked with the England job for the first time in his career. Reached the FA Cup final but league results tailed off badly. A slow start to this campaign has been followed by three successive Premier League victories.
5/6 Jurgen Klinsmann - 10/1
The former Tottenham striker has managerial experience at international level, having been in charge of the United States for almost five years and Germany before that. America fell to a semi-final Copa America exit in the summer while Klinsmann guided Germany to the last-four stage at the 2006 World Cup.
6/6 Gary Neville - 25/1
Seemed a heavy favourite to progress from his role as Hodgson's assistant until his ill-advised stint with Valencia saw his stock plummet. It may yet be decided that was a case of the wrong job but the right man. Out of coaching since exiting with Hodgson during the summer, the videos of Allardyce appear to show him saying Neville was the "wrong influence" on his predecessor.
Everton's Ross Barkley could also return for the first time since Euro 2016, while Alex Oxlade-Chamberlain and Andros Townsend are pushing for a recall. On-loan Bournemouth midfielder Jack Wilshere is still searching for form and fitness but is another in contention.
Tottenham striker Harry Kane, Manchester City midfielder Fabian Delph and Stoke goalkeeper Jack Butland are out, as is Adam Lallana after limping off after 20 minutes of Liverpool's 2-1 win at Swansea on Saturday lunchtime.
The attacking midfielder scored the winner against Slovakia last month - the only goal of the Allardyce era - but is struggling with a groin injury.
"Felt it, tried again, didn't work," Liverpool boss Jurgen Klopp said.
"In this moment, he has no chance for the national team but hopefully 15 or 16 days should be enough to bring him back on the pitch (for Liverpool).
"There was no sign of it in the week. These things can happen."
Eric Dier and Danny Rose have a chance to prove their fitness when Spurs host Manchester City on Sunday, as does United's Luke Shaw after a slight groin tear and illness.
There will be keen interest as to whether Wayne Rooney starts a third successive United match from the bench when Stoke arrive, but Southgate has already informed the forward that he will be remaining England captain.
The 30-year-old's position in the starting line-up, never mind his whereabouts on the field, for both club and country remains a hot topic of debate but the interim manager has spoken to the forward to tell him he will stay as skipper.
Southgate, who has held several roles at the FA over the years, is said to have long been impressed by Rooney's leadership and is keen for continuity.