Roy Hodgson has named four uncapped players in his squad for the upcoming games against Norway and Switzerland.
Jack Colback, Calum Chambers, Danny Rose and Fabian Delph are included in a new-look 22-man party.
The first match is a friendly against Norway next Tuesday, before their first Euro 2016 qualifier away in Switzerland on 8 September.
Tottenham winger Andros Townsend returns to the squad after missing the World Cup through injury and there is also a place for Everton's 20-year-old defender John Stones.
Chambers has caught the eye at Arsenal since his £16million move from Southampton and has earned a call-up despite the concerns of Gunners boss Arsene Wenger.
Danny Rose has been rewarded for his good early-season form with Tottenham and Fabian Delph comes into the squad because of his progress at Aston Villa.
It is Colback's call-up which comes as the biggest surprise.
The Newcastle midfielder has rarely been mentioned as a possible candidate for England duty, but Hodgson's hand has been forced by a series of injuries.
Kyle Walker (pelvis), Ross Barkley (knee), Theo Walcott (knee), Glen Johnson (thigh), Luke Shaw (hamstring), Michael Carrick (ankle), Jon Flanagan (knee), Adam Lallana (knee), Chris Smalling (groin), Kieran Gibbs (hamstring), Jay Rodriguez (knee) and Andy Carroll (ankle) are all missing through injury.
And with Steven Gerrard, Frank Lampard and Ashley Cole having now retired, there is an obvious lack of experience in the squad, which is set to meet on Sunday night.
England squad for the Euro 2016 qualifier against Switzerland and the friendly against Norway is as follows:
Forster (Southampton), Foster (West Brom), Hart (Manchester City); Baines (Everton), Cahill (Chelsea), Chambers (Arsenal), Jagielka (Everton), Jones (Manchester United), Rose (Tottenham), Stones (Everton); Colback (Newcastle), Delph (Aston Villa), Henderson (Liverpool), Milner (Manchester City), Oxlade-Chamberlain (Arsenal), Sterling (Liverpool), Townsend (Tottenham), Wilshere (Arsenal); Lambert (Liverpool), Rooney (Manchester United), Sturridge (Liverpool), Welbeck (Manchester United).