The MLS has held talks with the Premier League about organising a tournament involving American and English teams.
The MLS, now in its 20th year, has experienced a considerable growth in popularity over the last few seasons due to the success of the American national teams and an improved TV deal with worldwide broadcasters.
MLS Commissioner Don Garber believes popularity in football also grows in the States when the likes of Manchester United, Chelsea and Liverpool cross the Atlantic for pre-season tours.
10 Premier League debutants to watch this weekend
10 Premier League debutants to watch this weekend
1/10 Anthony Martial (Manchester United)
With a fee potentially rising to £58m, everyone is keen to get a look at the 'next Thierry Henry' when Manchester United play Liverpool at Old Trafford. Among them will be Wayne Rooney, who had to ask team-mate Morgan Schneiderlin who Martial was after United's shock mega-bid for the 19-year-old. Having made his France bow during the international break, Martial should be fit and ready to play.
2/10 Kevin De Bruyne (Manchester City)
Not strictly a Premier League debut for De Bruyne, who played three games for Chelsea during the 2013/14 campaign. The Blues didn't think much of the Belgian and let him leave for Wolfsburg. But just a couple of years later he's back following a £55m move to Manchester City. With question marks over his ability (and City's willingness to spend so much) in England, De Bruyne will be eager to show how much he's improved since his time at Chelsea.
3/10 Papy Djilobodji (Chelsea)
Jose Mourinho wanted John Stones. He got Papy Djilobodji. Whilst far from the mega-signing Chelsea had wanted, the 26-year-old Senegal international could prove a useful addition considering the Blues' shaky start to the defence of their Premier League crown. Having joined from Nantes on deadline day, the 6ft 3in central defender could go straight into the side when Chelsea play Everton at Goodison Park.
4/10 Ramiro Funes Mori (Everton)
A defender at the other end of the Goodison Park pitch potentially making his debut this weekend will be Funes Mori, who arrived at Everton on deadline-day for £9.5m. The Toffees have never paid so much for a defender, so supporters will be expecting much from the arrival from River Plate.
5/10 Virgil van Dijk (Celtic)
Another expensive defender to look out for this weekend is Virgil van Dijk, who joined Southampton from Celtic in a £13m deal. The ball-carrying centre-back joins the Premier League after back-to-back titles north of the border. Ronald Koeman will be hoping his Dutch compatriot can bring some consistency at the back - and maybe a goal or two with his aerial presence - after a mixed start to the season from Saints.
6/10 Heung-Min Son (Tottenham)
Tottenham were desperate to lessen the burden being placed on Harry Kane and whilst failing to sign Saido Berahino, did manage to bring in Heung-Min Son. £21.9m was needed to secure the signature of the striker from Bayer Leverkusen who scored 21 goals in 58 Bundesliga appearances for his former side. After a concerning start to the season that sees Spurs without a win, Mauricio Pochettino will be hoping Heung-Min can bring his international form to club level, with the South Korean scoring a hat-trick against Laos during the international break.
7/10 Michail Antonio (West Ham United)
West Ham were the most active side at the end of the transfer window, bringing in Victor Moses and Alex Song on loan and Nikica Jelavic on a permanent basis. All solid signings, but perhaps the most exciting will be pacy winger Antonio. He signed in a £7m deal after a hugely impressive season for Nottingham Forest last term. In 54 Championship appearances the 25-year-old was involved in 34 goals, netting 19 and providing a further 15 assists. Four of those goals came in this campaign before his move to Upton Park.
8/10 Dieumerci Mbokani (Norwich City)
Despite a healthy goal return since their return to the Premier League, Norwich have added another striker to their ranks with the addition of Mbokani on loan from Dynamo Kiev. The Democratic Republic of Congo international scored 16 goals in 33 league appearances for his former side and also boasted a strong return of 34 goals in 53 league appearances for former club Anderlecht. With fellow promoted side Bournemouth up this weekend, it could be a good opportunity for Mbokani to bag an early Premier League goal.
9/10 Victor Ibarbo (Watford)
Watford have looked decent on their return to the Premier League, but their failure to score in three of their four games means they've got little to show for it. That's why Ibarbo was brought in on loan from Cagliari. The Colombia international is not renowned for getting the goals himself - he's scored just 15 Serie A goals in 127 appearance - he is a shrewd playmaker. Quique Sanchez Flores will be hoping the 25-year-old can set up the goals that will fire his side up the table.
10/10 Joleon Lescott (Aston Villa)
Manchester City once paid £22m for Lescott, a signal of the quality the 26-times capped England international has. He might now be 33-years-old, but the £1m Aston Villa paid West Brom for his services seemed a bargain for a player who made 34 Premier League appearances last season.
Over the last two years all three clubs have participated in the International Champions Cup - an annual friendly tournament sponsored by Guinness - but Garber is hoping to create a more formal competition in which the most successful English teams compete.
"We have been talking to the Premier League about doing some sort of official competition as opposed to just having clubs come over to the country on a random basis playing in a tournament that takes place every summer," Garber said.
The Premier League said general talks had taken place, but the format of any potential tournament had not been discussed.
Garber's dream is to pit the top teams in America against their foreign counterparts - possibly from England - every summer.
"I would love to find a way that we could play our cup champion and our league champion against an FA Cup and league champion in a tournament and play it in New York City every year," he said.
"If not every year, then every four years.
"This concept of super cups involving the MLS, whether it's one with Mexico or one with some of the other leagues, would be smart.
"And many years ago they used to take place before MLS was in existence. It was called the Toyota Cup. That took place around the world.
He added: "Overall there is no doubt that there are opportunities for the MLS and Premier League to work more closely together on either a tournament or some other type of activity, but that is about as far as it has gone."
In future years, other major competition winners from across Europe could feature.
"You have calendar issues, but there is no reason why it couldn't (happen)," Garber said.
English influences on American soccer are nothing new, of course.
David Beckham took the MLS' profile to new heights when he signed for the Los Angeles Galaxy in 2007.
Garber hopes the league's profile will rocket again when Beckham's Miami franchise comes into existence.
Beckham has spent over a year trying to find a home for his franchise in the Floridian City. After protests from local residents, Beckham was forced to ditch plans to build a stadium in downtown Miami and has instead opted for a location next to the Miami Marlins baseball stadium.
The MLS commissioner hopes more big names will flock to the US once Beckham's team is up and running.
"I certainly believe that is what David would do," he said.
"That is what is motivating him to be part of the MLS ownership group. He says players are calling him all the time."
During United's recent tour of the US, Wayne Rooney said he would be consider playing in the MLS towards the latter stages of his career.
Unsurprisingly, that was music to Garber's ears.
"I was very pleased to hear that," he said.
Rooney's predecessor as England captain Steven Gerrard is already in the States playing for the Galaxy.
The former Liverpool skipper is not expected to return to his old club on loan this winter, according to Garber.
"I don't think so. And I had not heard that was something that was being contemplated," Garber added.
"That doesn't happen as much as it used to now. David (Beckham) knows very well that I was really upset when he went and played (on loan) in Milan.
"I don't belive we are going to see many more off season loans happening."