The Champions League favourites Arsenal will play London rivals Chelsea in the quarter-finals of the competition.
The two remaining Premiership sides in the competition - first and second in the domestic league - were paired together at UEFA's draw today.
The match will be the first encounter between two English sides in European competition since the country was readmitted following a six-year ban in 1991.
Manchester United's conquerors Porto were handed a tie with Lyon whilst nine-times winners Real Madrid will face Monaco. Holders AC Milan will play Deportivo La Coruna.
THE FULL DRAW
FC Porto v Lyon
Real Madrid v Monaco
Chelsea v Arsenal
AC Milan v Deportivo
First Legs to be played 23/24 March
Second Legs to be played 6/7 April
Real Madrid or Monaco v Arsenal or Chelsea
FC Porto or Lyon v AC Milan or Deportivo
First Legs to be played 20/21 April
Second legs to be played 4/5 May
Real Madrid or Monaco or Arsenal or Chelsea v FC Porto or Lyon or AC Milan or Deportivo