Louis van Gaal has reverted to the 3-5-2 formation that took the Netherlands to the World Cup semi-final, because of the current injury crisis at Manchester United.
Despite a lengthy injury list during the international break, a number of those players have been passed fit to start.
David De Gea, who dislocated a finger in Spain training, Luke Shaw, who came off at half-time against Scotland, Michael Carrick, who pulled out of the England squad, and Angel Di Maria, who hurt his ankle in a heavy challenge against Portugal, all start.
Van Gaal will play Chris Smalling alongside Paddy McNair and Tyler Blackett with Phil Jones, Jonny Evans and Rafael still out.
For Arsenal, Arsene Wenger has made two changes with Mikel Arteta and Jack Wilshere starting instead of Mathieu Flamini and Santi Cazorla.
Olivier Giroud has been named to the bench, but Theo Walcott has a groin problem and is not among the substitutes.
Arsenal: Szczesny, Chambers, Mertesacker, Monreal, Gibbs, Ramsey, Arteta, Wilshere, Oxlade-Chamberlain, Welbeck, Sanchez.
Subs: Martinez, Bellerin, Flamini, Rosicky, Cazorla, Podolski, Giroud.
Manchester United: De Gea, Smalling, McNair, Blackett, Valencia, Carrick, Fellaini, Shaw, Di Maria, Rooney, Van Persie.
Subs: Lindegaard, Fletcher, Herrera, Young, Mata, Januzaj, Wilson.Reuse content