Arsene Wenger has made one change to the team that was so impressive away at Aston Villa last week.
Jack Wilshere comes in for Santi Cazorla, who drops to the bench meaning £35m summer signing Alexis Sanchez remains among the substitutes.
The move would appear to indicate a move for Mesut Ozil from a central position, where he was so effective last week, to a a berth wide on the left.
Mauricio Pochettino has made three changes to a Tottenham team that disappointingly lost to West Brom at White Hart Lane last week.
The Spurs manager has had a defensive reshuffle with Kyle Naughton and Danny Rose coming in at the full-back positions to take the places of Vlad Chiriches and Eric Dier.
Ryan Mason, 23, is handed a Premier League debut after he impressed against Nottingham Forest in the Capital One Cup, where he scored a brilliant goal. Mousa Dembele is the man who makes way.
Arsenal: Szceczny, Chambers, Mertesacker, Koscielny, Gibbs, Ramsey, Wilshere, Arteta, Oxlade-Chamblerlain, Welbeck, Ozil.
Subs: Ospina, Coquelin, Flamini, Rosicky, Podolski, Cazorla, Sanchez.
Tottenham: Lloris, Naughton, Kaboul, Vertonghen, Rose, Capoue, Mason, Lamela, Erikssen, Chadli, Adebayor.
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