Louis van Gaal will hand Angel Di Maria his Manchester United debut at Turf Moor.
The Dutch coach will persist with his 3-5-2 formation, with Di Maria replacing Tom Cleverley in centre-midfield.
Van Gaal makes just one other change to the team that drew with Sunderland last week, Jonny Evans replacing injured centre-back Chris Smalling - Tyler Blackett keeps his place in the team with Marcos Rojo unavailable to play as he still doesn't have a work permit.
Javier Hernandez and Danny Welbeck are named among the substitutes despite being linked with a move away from Old Trafford.
Sean Dyche's Burnley may have lost both of their opening matches but the manager is persisting with the same starting XI for the third match in a row.
Burnley: Heaton, Trippier, Duff, Shackell, Mee, Arfield, Jones, Marney, Taylor, Ings, Jutkiewicz.
Subs: Gilks, Ward, Reid, Long, Wallace, Sordell, Barnes.
Manchester United: De Gea, Jones, Evans, Blackett, Valencia, Young, Fletcher, Di Maria, Mata, Rooney, Van Persie.
Subs: Januzaj, Hernandez, Welbeck, James, M. Keane, Anderson, Amos.