Jose Mourinho has made four changes to the team that drew 1-1 with Paris Saint-Germain in midweek.
Gary Cahill, who was blamed for the Edinson Cavani equaliser, again loses his place to promising centre-back Kurt Zouma.
There is another change in defence as Filipe Luis comes in for Cesar Azpilicueta, while Brazilian pair Ramires and Willian drop to the bench in favour of Juan Cuadrado and Oscar, who comes back from injury.
Chelsea could stretch their lead to 10 points over rivals Manchester City, who play at 5.30pm, with a win.
Sean Dyche starts with the same XI who lost at Old Trafford last week.
Chelsea: Courtois, Ivanovic, Zouma, Terry, Filipe Luis, Matic, Fabregas, Cuadrado, Oscar, Hazard, Diego Costa.
Subs: Cech, Azpilicueta, Cahill, Ramires, Willian, Drogba and Remy.
Burnley: Heaton; Trippier, Shackell, Keane, Mee; Boyd, Jones, Arfield, Kightly, Barnes, Ings.
Subs: Gilks, Duff, Wallace, Vokes, Reid, Jutkiewicz, Ward.Reuse content