Chelsea manager Jose Mourinho makes just one change from the side who were knocked out of the Champions League by Paris Saint Germain last week.
Willian comes in for Ramires as the Blues come out fighting after a turbulent week for the London club.
Southampton, on the other hand, are still fighting for a top four spot and hope Shane Long, back in the side this afternoon, can fire them to a shock victory.
Ronald Koeman's line-up is an attacking one, with Dusan Tadić playing opposite Sadio Mané, while Mourinho hands starts to Cesc Fabregas and Nemanja Matic.
Chelsea: Courtois; Ivanovic, Cahill, Terry (c), Azpilicueta; Matic, Fabregas; Willian, Oscar, Hazard; Diego Costa.
Subs: Cech, Filipe Luis, Zouma, Ramires, Cuadrado, Remy and Drogba.
Southampton: Forster, Clyne, Fonte (c), Alderweireld, Bertrand, Wanyama, Schneiderlin, S. Davis, Tadić, Mané, Long.
Subs: K. Davis (GK), Yoshida, Gardos, Djuričić, Ward-Prowse, Pellè, Targett.Reuse content