West Ham United travel to Selhurst Park without the influential presence of Kevin Nolan while James Collins also misses out through suspension.
Nolan, out with a shoulder injury, could be sorely missed by Sam Allardyce's men after the opening day defeat to arch rivals Tottenham Hotspur.
Barry Bannan, meanwhile, starts for the Eagles in place of the suspended Jason Puncheon. The Scotland international's inclusion is one of two changes made by caretaker boss Keith Millen.
Damien Delaney replaces the injured Scott Dann at the heart of Palace's defence as the search for a new manager, and first victory of the season, continues.
Crystal Palace: Speroni, Ward, Hangeland, Kelly, Ledley, Bolasie, Jedinak, Bannan, Delaney, Chamakh, Campbell.
Subs: Hennessey, Mariappa, McCarthy, O'Keefe, Jonny Williams, Murray, Gayle.
West Ham United: Adrian, O'Brien, Tomkins, Reid, Cresswell, Noble (c), Kouyate, Downing, Zarate, Vaz Te, Cole.
Subs: Jaaskelainen, Demel, Poyet, Morrison, Diame, Valencia, Sakho.