Everton midfielder Marouane Fellaini has been ruled out for up to six weeks with a hamstring injury.
The 22-year-old was hurt playing in Belgium's Euro 2012 qualifier against Austria in midweek.
The injury is a fresh setback for Fellaini, who missed the final three months of last season after damaging ankle ligaments in a Merseyside derby against Liverpool.
Manager David Moyes said: "It is a very big blow because he is an important player for us."
Liverpool, coincidentally are Everton's next opponents at Goodison Park on Sunday.
Defender Phil Jagielka is also unlikely to feature after suffering a hamstring injury in training with England.
Moyes added: "He is not as bad as we first thought but it may just come too quick for him - that is the way it is looking at this moment in time."
Louis Saha, who has been out since August with a calf problem, is also unlikely to return.
The new injuries came in the same week youngster Ross Barkley, who has been on the bench for the last four games, broke a leg.