David Moyes has confirmed Wayne Rooney and Robin van Persie trained on Monday morning and could return for Manchester United's Barclays Premier League encounter with Cardiff at Old Trafford on Tuesday.
Rooney has been missing with a groin strain since the New Year's Day defeat by Tottenham, whilst Van Persie suffered a thigh problem in the Champions League win over Shakhtar Donetsk last month.
However, both are in contention to face Ole Gunnar Solskjaer's men, along with £37.1million new-boy Juan Mata, who is set to make his debut.
"They have all trained today," said Moyes.
Moyes could also have midfielder Marouane Fellaini back after wrist surgery.
Meanwhile, the United boss has dismissed rumours of a big-money bid for teenage sensation Adnan Januzaj from Paris St-Germain.
"I think you have been listening to too much speculation," said Moyes to a question about Januzaj's future.
"Adnan is very much part of what we are doing and it will continue to be that way."
Meanwhile, Moyes has side-stepped questions over the future of Rooney, whose contract expires in 2015 but has been linked with a massive extension, that could net him £300,000 a week.
"It is one I have left with (executive vice-chairman) Ed Woodward and Wayne and his advisors," said Moyes.
"We will give you an update on it at the right time. Right now I would prefer to talk about his performances."
Moyes might find himself in rather a strange situation on Tuesday given the reception for the opposing manager is going to be far more enthusiastic than his own given the depth of feeling for Solskjaer at Old Trafford.
Yet the Scot feels such accolades are fully deserved.
"He deserves it because of what he has done here," said Moyes.
"He won the Champions League and was a great ambassador for Manchester United."
Manchester United's most expensive signings... were they worth it?
Manchester United's most expensive signings... were they worth it?
1/12 Juan Mata - £37m - January 2013
Spain midfielder Juan Mata arrives from Chelsea as a proven dynamo in midfield. During his two full seasons at Chelsea, he was voted their player of the season.
But will he be a success? As the following slides show, spending lots of money isn't always the answer
2/12 Dimitar Berbatov - £30.75m - September 2008
Manchester United spent the summer of 2008 pursuing Tottenham striker Dimitar Berbatov, but it was just a dramatic few minutes before the close of the transfer window that they got their man. And the Bulgarian didn't come cheap at £30.75m - United's most expensive ever signing (until Mata).
Compared with Eric Cantona upon his arrival, Berbatov fell well short of expectations. 48 league goals in 108 appearances is not a bad return, but that he didn't even make the bench for the 2011 Champions League final against Barcelona spoke volumes.
Best remembered for his saved penalty against Everton in the semi-final of the 2009 FA Cup in which his casual spot-kick made him look like a plonker, and on the flip-side, his hat-trick against Liverpool in 2010.
Sold to Fulham for around £5m in 2012.
3/12 Rio Ferdinand - £29.3m - July 2002
When United paid Leeds United £29.3m back in 2002, it appeared a crazy amount of money to spend on a defender. Yet Rio Ferdinand has been a linchpin of the squad in the intervening decade (excluding the eight months he was banned for missing a drugs test) and was worth every penny.
United won the league in his first season and another five after that. He also helped United win the Champions League in 2008.
4/12 Juan Sebastián Verón - £28.1m - July 2001
The arrival of Juan Sebastián Verón from Lazio was one of the most glamourous signings in the history of the Premier League - yet sadly for United it was only that, with little substance to the £28.1m man.
The Argentine never settled at Old Trafford and made just 51 league appearances in which he scored seven goals. Two years after arriving, he was sold to Chelsea (who incredibly paid £15m for a player who would make just 14 appearances for the west Londoners).
5/12 Wayne Rooney - £27m - August 2004
After bursting onto the scene at Goodison Park, and then appearing as though he could carry England to the Euro 2004 title before injury struck, it was obvious Everton would not be able to hold on to their boy wonder.
And it was Manchester United who came calling, splashing out £27m on the then 18-year-old. It was a huge fee for such a young player - but in retrospect a bargain. On his debut he scored a Champions League hat-trick against Fenerbahce and he never looked back. Rooney is currently the fourth highest scorer in Manchester United's history.
6/12 Robin van Persie - £24m - August 2012
Robin van Persie, Ferguson's final big-name signing, scored 30 goals in his first season at the club as United reclaimed the title from Manchester City with ease.
There is no doubt that the Dutchman is among the best in the Premier League, but injury problems under David Moyes have raised concerns that he fitness record at Old Trafford could be as frustrating as when he was at Arsenal.
7/12 Anderson - £20.4m - July 2007
Still only 25-years-old, there remains perhaps a little more time for Anderson to justify why United paid Porto in excess of £20m for the midfielder's services.
Yet it must be said that the box-to-box midfielder has been disappointing in the six-years he's spent at Old Trafford, showing only marginal progress during that period. Although, if Anderson does nothing else, he will be able to say he scored United's sixth attempt from the penalty spot in the 2008 Champions League final against Chelsea. John Terry missed with the next spot-kick as United claimed their third European Cup triumph.
8/12 Ruud van Nistelrooy - £19m - June 2001
Alex Ferguson pursued Ruud van Nistelrooy for years, and it was only injuries that stopped the Dutch striker transferring from PSV Eindhoven to United earlier. He would be worth the wait.
In 150 league appearances he would score 95 goals, while his record in the Champions League was incredible. During his time at United he scored 38 Champions League goals - more than any other United player in the club's history. After five-years at the club he was sold to Real Madrid.
9/12 David de Gea - £18.9m - June 2011
United needed to replace the retiring Edwin van der Sar with a top-class stopper, yet while David de Gea clearly had ability, Ferguson's decision to put his faith in a 20-year-old with relatively little experience surprised many.
Signed from Atlético Madrid in the summer of 2011, the Spaniard started shakily but has since silenced the doubters (barring his horrendous error against Sunderland in the Capital One Cup semi-final)
10/12 Michael Carrick - £18.6m - July 2006
Another player Tottenham reluctantly sold to United, Michael Carrick has been a consistent force in Ferguson's midfield since joining in 2006.
Among other honours, the England international has five league titles to his name and a Champions League medal. There are few better passers in the Premier League, but his inability to find the back of the net remains a frustration.
11/12 Nani - £17.3m - July 2007
Unfairly compared to his countryman Cristiano Ronaldo after arriving from Sporting Lisbon in 2007, Nani had a slow start to his Old Trafford career.
Yet he has showed signs of breaking free of those shackles, netting 10 goals from midfield in both the 2010/11 and 2011/12 season. Despite signing a new contract after the arrival of David Moyes, he continues to be linked with a move away.
12/12 Owen Hargreaves - £17m - July 2007
Consistent displays at the heart of Bayern Munich's midfield, and then impressive performances in an England shirt under Sven Goran-Eriksson brought Owen Hargreaves to the attention of the British public, and Alex Ferguson, and in the summer of 2007 he joined Manchester United in a £17m deal.
Some described him as one of the most naturally talented midfielders England had ever seen - yet Manchester United fans didn't get much of a chance to see for themselves. Injuries would limit Hargreaves to just 39 appearances for the club before he was released.