Marcos Rojo returns for Manchester United after dislocating his shoulder in their 1-0 defeat to Manchester City a month ago.
The Argentine lines up alongside Chris Smalling and Michael Carrick in central defence, as Paddy McNair and Tyler Blackett drop to the bench.
Juan Mata makes a rare start, while Ashley Young keeps his place after impressing as a substitute for the injured Luke Shaw against Arsenal last week.
Radamel Falcao and Ander Herrera both return to the bench after lengthy lay-offs.
Hull are missing Gaston Ramirez, who is serving a suspension after being sent off against Spurs, and is replaced by the French playmaker Hatem Ben Arfa.
Abel Hernandez, who is attending the birth of his child, is also unavailable.
Manchester United: De Gea, Smalling, Carrick, Rojo, Valencia, Fellaini, Mata, Di Maria, Young, Rooney, van Persie
Subs: Lindegaard, Blackett, McNair, Fletcher, Herrera, Januzaj, Falcao
Hull: McGregor, Dawson, Chester, Davies, Robertson, Livermore, Diame, Elmohamady, Brady, Ben Arfa, Jelavic
Subs: Jakupovic, Rosenior, Bruce, Meyler, Huddlestone, Aluko, QuinnReuse content