Manchester United manager Louis van Gaal will hope that his players respond to his claim that they can still win the Premier League title when Southampton travel to Old Trafford for this afternoon's encounter.
United rocked after Ashley Young ruled out for "a very long time" with groin injury
Young joins Luke Shaw, Antonio Valencia and Marcos Rojo on long-term injury list
Bastian Schweinsteiger, Phil Jones and Michael Carrick also absent
Saints could hand debut to Charlie Austin following his £4m move last weekend
Striker Graziano Pelle misses out with a knee injury
Manchester United: De Gea, Darmian, Smalling, Blind, Borthwick-Jackson, Schneiderlin, Fellaini, Lingard, Herrera, Martial, Rooney.
Subs: Romero, McNair, Varela, Pereira, Januzaj, Mata, Memphis.
Southampton: Forster; Soares, Fonte, Van Dijk, Targett; Clasie, Wanyama; Mane, Tadic, Betrand; Long.
Subs: Stekelenburg, Yoshida, Romeu, Martina, Ward-Prowse, Juanmi, Austin.
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Norwich vs Liverpool - 12.45pm
Crystal Palace vs Spurs - 3pm
Leicester vs Stoke - 3pm
Manchester United vs Southampton - 3pm
Sunderland vs Bournemouth - 3pm
Watford vs Newcastle - 3pm
West Brom vs Aston Villa - 3pm
West Ham vs Manchester City - 5.30pm