League leaders Chelsea travel to The Emirates still unbeaten in the league and on the back of a 6-0 drubbing of Wolves in the Capital One Cup in midweek.
Arsenal also hit six in the League Cup and will be looking to build on an impressive draw earned at Manchester City last weekend. The Gunners will want a similar display to prove their worth as title challengers.
Chelsea captain John Terry is expected to lead his side out despite being found guilty, by The FA, of racially abusing Anton Ferdinand in a match between QPR and Chelsea in October last year. Terry was handed a four-game ban by The FA but is available for selection as he is yet to accept the ban.
Arsene Wenger has a full squad to choose from as long-term absentees Bacary Sagna, Tomas Rosicky and Jack Wilshere return to full training.
KICK-OFF: Saturday, 12.45pm
PAST THREE MEETINGS…
Arsenal 0-0 Chelsea, Premier League, April 2012
Chelsea 3 (Lampard, Terry, Mata) Arsenal 5 (Van Persie 3, Andre Santos, Walcott) Premier League, October 2011
Arsenal 3 (Song, Fabregas, Walcott) Chelsea 1 (Ivanovic), Premier League, December 2010
Arsene Wenger completes 16 years in charge of the Gunners on Monday. Victory over Chelsea would hand him his 350th Premier League win as Arsenal boss.
Chelsea's only dropped points so far this term came in the capital: a goalless draw at QPR earlier this month.
Roberto Di Matteo's men have not conceded in their last 331 league minutes since Danny Guthrie's goal in August's 4-2 win over Reading.
Frank Lampard has scored 98 Premier League goals in London. He can become only the second player to net 100 goals in the capital after Thierry Henry (133 goals).
Arsenal to win: 2.15
Chelsea to win: 3.25
TV: Live on Sky Sports 1 at 12.45pm, highlights on BBC1 at 10.10pm