Tottenham are unbeaten in their last eight matches against Aston Villa.
Villa have won only one of their last seven fixtures against Spurs at Villa Park.
Defeat at Stamford Bridge ended a five-game unbeaten Premier League run for Paul Lambert's side. Lambert's team are the Premier League's joint lowest scorers.
Aston Villa skipper Ron Vlaar (calf), Gabriel Agbonlahor (thigh) and Charles Nzogbia (knee) all face late fitness tests. Darren Bent is out with a a hamstring injury.
Clint Dempsey is a doubt with a groin problem, but Benoit Assou-Ekotto could return from a knee injury for Tottenham. Scott Parker could earn his first start of the season.
KICK-OFF: Wednesday 5.30pm
PAST THREE MEETINGS…
Tottenham 2 (Caulker, Lennon), Premier League, October 2012
Aston Villa 1 (Clark) Tottenham 1 (Adebayor), May 2012
Tottenham 2 (Adebayor 2) Aston Villa 0, Premier League, November 2011
Defeat at Stamford Bridge ended a five-game unbeaten Premier League run for Paul Lambert's side.
Tottenham are unbeaten in their last eight matches against Aston Villa (W5, D3) since a 2-1 home defeat in September 2008.
Villa have taken just 18 points from their last 21 home league matches (W3, D9, L9).
Spurs have lost three of their last four Premier League away games.
Tottenham have suffered only two defeats in their last 18 Premier League games in the month of December
Aston Villa to win: 3.65
Tottenham to win: 2.2
TV: Live on Sky Sports 5.30pm, Highlights on BBC1 at 10.25pm on MOTD