Alan Pardew will be struggling when Newcastle visit Arsenal on Saturday, with the manager having up to 10 senior players missing.
Newcastle, who ended Chelsea's 23-match unbeaten run last weekend, will be hoping to continue their fine run of form with another victory at the Emirates, but Pardew will be forced to start young goalkeeper Jak Alnwick, with both Tim Krul and Rob Elliott likely to be out until January.
Alnwick, 21, played the second-half against the Blues last Saturday, pulling off an important save from Diego Costa as time was winding down at St James' Park.
Club captain Fabricio Coloccini and Mehdi Abeid both face late fitness tests to face Arsenal, while Ryan Taylor, Gabriel Obertan and Davide Santon remain sidelined.
Arsenal will have seven players missing for the same game, with Mathieu Debuchy likely to play at centre-back on his return to Premier League action after missing the last three months.
Aaron Ramsey, Jack Wilshere, Mesut Ozil and Theo Walcott will also miss the game.
Louis van Gaal's injury struggles continue, with Chris Smalling and Phil Jones out, although Jonny Evans did return against Southampton. Angel Di Maria has also been ruled out of the game but Rafael could return for the clash with bitter rivals Liverpool at Old Trafford. Brendan Rodgers will still be without Daniel Sturridge but Mario Balotelli could play for the first time in a month.
Arsenal's injury list
Arsenal's injury list
1/5 Mikel Arteta (midfield)
Like Diaby, the Spaniard is closing in on a return but the Swansea match will come to soon. The club captain last played in November.
2/5 Mathieu Debuchy (defender)
Returned in the FA Cup semi-final win over Reading but has since been ruled out with injury and Wenger confirmed he remains 'unavailable'.
3/5 Alex Oxlade-Chamberlain (midfield)
Suffered a hamstring injury against Manchester United in the FA Cup and hasn't played since as it has exacerbated a groin problem. Out at least until May and facing surgery in the summer.
4/5 Aaron Ramsey (midfield)
Aaron Ramsey caught a kick on his calf during the win over Hull and was later substituted. The Welshman was rated 50/50 for the Swansea match by Wenger, but it now appears that he is a major doubt for the clash at the Emirates.
5/5 Danny Welbeck (forward)
Danny Welbeck has not played since the goalless draw with Chelsea towards the end of April after suffering a knee injury. Wenger has confirmed that the injury is 'nothing major', and that he should return to full fitness before the end of the season.
Aston Villa could also have eight players, though three of those face late fitness tests.
Tottenham have just one player missing, Kyle Naughton, with Kyle Walker making his first appearance in nine months in the 1-0 defeat to Besiktas on Thursday night.