Billed as the game of the season so far, the two Manchester clubs will fight it out at the Etihad on Sunday afternoon as United look to extend their lead at the top of the table, which currently stands at three points over their rivals.
Both teams have failed to reach their optimum level of performance this season, but both still occupy the top two places in the league, with City the only unbeaten team in England - which is overshadowed by their disastrous Champions League campaign.
Alex Ferguson has admitted this weekend's game is a big test for his players, especially with their recent poor defensive displays. The Scot has admitted a win at the Etihad this Sunday would rank "as the finest of his career".
KICK-OFF: Sunday, 1.30pm
PAST THREE MEETINGS…
Manchester City 1 (Kompany) Manchester United 0, Premier League, April 2012
Manchester City 2 (Kolarov, Aguero) Manchester United 3 (Rooney 2, Welbeck), FA Cup, January 2012
Manchester United 1 (Fletcher) Manchester City 6 (Balotelli and Dzeko 2, Aguero, Silva), Premier League, October 2011
United have won six of their last seven games.
City have won just four of their last 11 games, losing two and drawing five.
Manchester United have the most potent attack in the league with 37 goals to date.
Despite defensive errors costing City dear in the Champions League, they have the sturdiest defence in the league, conceding just 11 goals.
Manchester City to win: 2.28
Manchester United to win: 3.4
TV: Live on Sky Sports 1, 1.30pm