Manchester United may not have anything to play for since securing the league title, but Sir Alex Ferguson has vowed his side will not let up against Chelsea and rival Rafael Benitez.
Chelsea are under pressure to cement their position in the precious Champions League places. The Blues may look comfortable sitting on top of Arsenal and Tottenham, with a game in hand over the former, but they have arguably the most difficult run-in to the end of the season.
After the trip to Manchester, Chelsea must welcome Tottenham and Everton to the Bridge, with a visit to Aston Villa in between. And, having not won at Old Trafford since 2010, the odds do not stack in their favour to pick up the points on Sunday.
But after their FA Cup quarter-final fightback in March, Chelsea will have confidence they can score goals to give themselves a good chance of securing a victory.
KICK-OFF: Sunday, 4pm.
PAST THREE MEETINGS…
Chelsea 1 (Ba), Man United 0, FA Cup quarter-final, April 2013
Man United 2 (Hernandez, Rooney) Chelsea 2 (Hazard, Ramires), FA Cup quarter-final, March 2013
Chelsea 5 (Luiz, Cahill, Hazard, Sturridge, Ramires) Man United 4 (Giggs 2, Hernandez, Nani), Capital One Cup 4 round, October, 2012.
Chelsea have not beaten Manchester United in the league since March 2011 and have not won at Old Trafford since April 2010.
These teams have scored 19 goals between them in the four times they have met this season.
Chelsea have played 64 games this season, more than any other club in the Premier League.
Manchester United have only lost twice at home in the league this season.
Man United to win: 2.26
Chelsea to win: 3.55
TV: Live on Sky Sports 1 at 4pm, highlights on BBC 1 at 10.25pm.