This weekend both sides will be looking to take a lead in the race for third place position in the Premier League. With Ronald Koeman's team visiting Old Trafford for this latest meeting, the Saints will be desperate not to repeat December’s match where United won 2-1.
Louis van Gaal’s side are in strong form of late and are unbeaten in their last six matches.
One of Southampton’s most recent defeats came from the red side of Manchester. Will they be able to stop United in their tracks come Sunday?
KICK-OFF: Sunday, 4pm
PAST THREE MEETINGS…
Southampton 1 (Pelle) Manchester United 2 (van Persie 2), Premier League, December 2014
Southampton 1 (Lambert) Manchester United 1 (Mata), Premier League, May 2014
Manchester United 1 (van Persie) Southampton 1 (Lallana), Premier League, October 2013
Over the past three meetings for the teams Robin van Persie has scored 3 goals for Manchester United.
Out of all of the Premier League games where the two teams have met Manchester United have won 49 games, with Southampton only triumphing in 23.
Strikers Wayne Rooney and van Persie (Manchester United) and Graziano Pellè (Southampton) have all scored 8 goals for their team this season.
Manchester United to win: 5/6
Southampton to win: 4
TV: Highlights on BBC1 at 10.30pm.