Manchester City will be looking to crank up the pressure on neighbours and title rivals, Manchester United. A win against the bottom club would see City cut the gap to two points, with United to play on Wednesday night.
QPR are in dire need of the win, five points adrift at the bottom of the Premier League. Despite losing at the weekend in the FA Cup, QPR are unbeaten in their last three league games.
Rangers boss Harry Redknapp will bring in several first team players after the huge cup defeat at home to League One MK Dons, with Loic Remy and Adel Taarabt expected to be recalled to provide firepower for the Hoops.
City captain Vincent Kompany is ruled out after limping off against Stoke on Saturday with a calf injury. Joe Hart, who could take the armband, is set to make his 150th Premier League appearance for the champions. Brothers Kolo and Yaya Toure are still away on international duty with Ivory Coast.
PAST THREE MEETINGS...
Man City 3 (Yaya Toure, Dzeko, Tevez) QPR 1 (Zamora) - September 2012 - Premier Leagye
Man City 3 (Zabaleta, Dzeko, Aguero) QPR 2 (Cisse, Mackie) - May 2012 - Premier League
QPR 2 (Boothroyd, Helguson) Manchester 3 (Dzeko, Silva, Yaya Toure) - November 2011 - Premier League
Manchester City recorded their legendary 3-2 title win on the final day of the last season against QPR, snatching victory and the title away from Manchester United through Sergio Aguero's injury time strike.
The game in May also marked a special occasion, Joey Barton's last appearance in a QPR shirt, after headbutting Sergio Aguero in a fit of rage, the midfielder has since gone on a season-long loan to French side, Olympique Marseille.
Edin Dzeko has found the net in each of his last three games against the Hoops.
City have their last four on the bounce in the league whilst QPR, have lost one, won one and drawn two in that same period.
QPR to win: 7.00
Manchester City to win: 1.50
TV: Highlights BBC1 10.30pm, Wednesday 30th.