Both of these sides have done little to disprove the pre-season prediction that the pair will be relegated come the end of the season, with both sides in the bottom three ahead of this clash.
One thing that hasn't been a problem for either has been scoring goals, but both have been defensively poor, conceding a total of 32 and 27 goals respectively.
The Saints lie three points ahead of their relegation rivals, in what can only be described as a 'six-pointer' on Saturday afternoon.
Reading have yet to win away this season, whereas the Saints are unbeaten in their last three home game.
KICK-OFF: Saturday, 3pm
PAST THREE MEETINGS…
Southampton 1 (Lambert) Reading 3 (Le Fondre 2, Roberts), Championship, April 2012
Reading 1 (Leigertwood) Southampton 1 (De Ridder), Championship, October 2011
Southampton 1 (McGoldrick) Reading 1 (Long), Championship, December 2008
Southampton have the worst defensive record in the Premier League - conceding 32 goals so far in the league alone.
Reading have lost their last three matches and find themselves second bottom - just three points above bottom club QPR, who remain winless.
The Saints have a win percentage of just 20 per cent this season.
The Royals have a win percentage of only 7 per cent, only QPR have a worse record in the Premier League.
Southampton to win: 1.97
Reading to win: 4.3
TV: Highlights on BBC 1, 10.30pm