Manchester City will be without star striker Sergio Aguero when they face Juventus in the opening game of the Champions League group stages.
Aguero hurt his knee after a hefty challenge from Palace defender in the first-half of Manchester City's 1-0 win over Crystal Palace at Selhurst Park on Sunday.
The 27-year-old did not train with the rest of the squad ahead of Tuesday's European encounter at the Etihad Stadium and Pellegrini later revealed he would not play in the match.
He suffered knee ligament damage last year which kept him out for a month.
Speaking at his pre-match press conference, Pellegrini said: "Sergio is not fit for tomorrow. He has a kick in his knee. It is difficult for him."
Aguero, last season's top scorer, could return for Saturday's Barclays Premier League clash with West Ham.
Pellegrini said: "I hope so but we must wait. We will see this afternoon how long it will be."
On the positive side, David Silva and Raheem Sterling, who missed the Palace game with ankle and hamstring problems respectively, did both train and will be expected to be fit.
Samir Nasri and Fernandinho both sat out the full session because of minor knocks but Pellegrini said he hoped "both will be 100 per cent fit tomorrow".
Additional reporting from PA
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