Filip Djuricic and Eljero Elia were drafted in by Ronald Koeman as Southampton looked to get back to winning ways against Crystal Palace.
The on-loan duo replaced Florin Gardos and Dusan Tadic in the starting line-up at St Mary's, where Toby Alderweireld was on the bench following a hamstring problem.
Alan Pardew made three changes against his former club, with Dwight Gayle, James McArthur and Joe Ledley coming in for Palace.
Southampton: Forster, Clyne, Fonte, Yoshida, Bertrand, Wanyama, Schneiderlin, Elia, Djuricic, Mane, Pelle.
Subs: Kelvin Davis, Gardos, Long, Steven Davis, Tadic, Ward-Prowse, Alderweireld.
Crystal Palace: Speroni, Ward, Dann, Delaney, Kelly, Ledley, Zaha, Puncheon, McArthur, Bolasie, Gayle.
Subs: Mariappa, Hangeland, Hennessey, Ameobi, Boateng, Gray, Souare.
Referee: Martin Atkinson (W Yorkshire)