The two sides have dropped down a place in the table owing to West Ham's win yesterday but a point for Southampton will return them to third place whilst victory for Manchester United will take them into pole position behind Manchester City and Chelsea.
With Jose Mourinho's league leaders suffering a rare slip, this game also represents a chance for these two from the chasing pack to close the gap to the summit.
Southampton come into the game having suffered a blip in form, with defeat to Manchester City and Arsenal coming in the last couple of weeks.
In contrast, United have won their last four in a row and now look like a team that should be in the mix for the Champions League places come the end of the season.
- The match kicks off at 8pm
- These sides drew 1-1 in both meetings last season
- This will be the first Premier League game to be contested by their two Dutch managers
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