Louis van Gaal revealed that the Colombian striker is incapable of playing for more than 20 minutes at a time (something his wife refutes) in the build-up to tonight's match at St Mary's. It's likely the on-loan striker will get his chance from the bench, as he has done in United's last two matches.
Wayne Rooney returns to the starting line-up having missed last week's victory over Stoke City. The captain has recovered from a knee injury sustained against Hull City. He partners Roboin van Persie in attack.
Angel Di Maria remains out with a hamstring injury.
For Southampton midfielder Jack Cork is out, and will be for six weeks, with an ankle injury.
Toby Alderweireld and Morgan Schneiderlin are also out for the hosts but Dusan Tadic has overcome a knock and is in the starting XI.
Southampton XI: Forster, Clyne, Yoshida, Fonte, Bertrand, Davis, Mane, Tadic, Wanyama, Long, Pelle
Subs: K. Davis (GK), Gardos, Mayuka, Isgrove, Reed, Targett, Hesketh
Manchester United XI: De Gea, McNair, Smalling, Rojo, Valencia, Carrick, Fellaini, Young, Mata, Rooney, van Persie
Subs: Lindegaard, Evans, Herrera, Fletcher, Januzaj, Wilson, FalcaoReuse content