Manchester United welcome back Robin van Persie to their starting line-up while Radamel Falcao starts on the bench.
The Colombian has scored just four times on 19 appearances for the Red Devils despite reportedly being on £265,000-a-week at Old Trafford.
Louis van Gaal, the United manager, also hands starts to Wayne Rooney and Angel di Maria while Daley Blind anchors the midfield once again.
Swansea, on the other hand, are buoyed by the return of Gylfi Sigurdsson after serving a three-match suspension for the red card he picked up against Blackburn.
Wayne Routledge also returns to Gary Monk's side after injury, but Kyle Bartley has been ruled out for six weeks with a knee problem.
Swansea City: Fabianski, Naughton, Fernandez, Williams (C), Taylor, Cork, Shelvey, Ki, Sigurdsson, Routledge, Gomis.
Subs: Tremmel, Rangel, Amat, Britton, Montero, Emnes, Oliveira.
Manchester United: De Gea, McNair, Jones, Rojo, Shaw, Blind, Fellaini, Herrera, Di Maria, Rooney, van Persie.
Subs: Valdes, Smalling, Januzaj, Mata, Valencia, Young, Falcao.Reuse content