Palermo president Maurizio Zamparini has confirmed Tottenham have made a 35million euro bid for star duo Simon Kjaer and Edinson Cavani.
Denmark centre-half Kjaer and Uruguay forward Cavani have both starred at the World Cup, prompting the bid from Spurs who will play in the qualifying rounds of next season's Champions League.
Boss Harry Redknapp has had issues in defence with Ledley King and Jonathan Woodgate both struggling with long-term injury problems while Cavani would boost an attacking line-up which already features the likes of Jermain Defoe, Peter Crouch and Roman Pavlyuchenko.
Spurs' bid appears to have been accepted by Palermo with Zamparini already earmarking the transfer fee for rebuilding.
He told Sky Italia: "Tottenham have bid 35 million euros, an offer we cannot refuse, seeing as the two players have both said they want to leave.
"We will reinvest the money for these players. The midfield is my biggest concern, whereas in defence and attack we are fairly well covered."
Palermo signed 21-year-old Kjaer from FC Midtjylland in 2008 and a string of impressive performances in Serie A have brought him to the attention of Europe's leading clubs.
Cavani, 23, was equally unknown when he moved to the Sicilian club from Danubio in 2008.