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Ahead of the match at St. Mary's, we take a look at how the sides' players Victor Wanyama and Marouane Fellaini compare.
Southampton had a flying start of the season but it looks like that momentum might be fading away. Defeats to Manchester City and Arsenal saw Ronald Koeman's side slip down to third and United are on their heels with only one point behind.
Louis van Gaal’s team appear to have turned the corner, winning their last four games. United struggled earlier on in the season but look like serious top four contesters again.
United’s injury list is gradually decreasing with Radamel Falcao and Wayne Rooney should be fit for Monday's game, although Angel di Maria, Luke Shaw and Daley Blind remain unavailable.
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