Radamel Falcao returns to the Manchester United starting XI for today's match at West Ham. The Colombian striker was an unused substitute in United's 3-0 FA Cup fourth-round win over Cambridge United last Tuesday.
For West Ham, their striker Andy Carroll misses out with an ankle injury.
A victory over today would see United move up to third place, and reduce the gap on leaders Chelsea to 10 points. Their defender, Marcos Rojo, has not give up hope of wining the title.
"I thought Chelsea were far ahead of us in the table, but everyone at United says we can catch them," the Argentinian, who signed from Sporting Lisbon for £16m over the summer, said.
"We will not give up hope. We'll first aim to overtake Manchester City, and it is a good challenge for us."
West Ham: Adrian, Jenkinson, Tomkins, Kouyate, Cresswell, Song, Noble, Nolan, Downing, Sakho, Valencia.
Subs: Jaaskelainen, O'Brien, Oxford, Amalfitano, Jarvis, Cole, Lee.
Manchester United: De Gea, Valencia, Jones, Rojo, Shaw, Blind, Rooney, Januzaj, Di Maria, Falcao, van Persie.
Subs: Valdes, Smalling, McNair, Fellaini, Herrera, Mata, Wilson.