Super League newcomers Salford will have the distinction of launching the 'Magic Weekend' in Edinburgh in May.
The City Reds' fixture against Harlequins will be the first of three at Murrayfield on Saturday 2 May, followed by Bradford versus Wakefield and the derby between Wigan and St Helens.
The expansion of Super League to 14 clubs means a marathon of four games on the Sunday, starting with the other new boys, the Celtic Crusaders, against Huddersfield. That will be followed by Hull versus Castleford and Leeds v the Catalans, before Warrington and Hull KR wrap up the weekend.
The extra round of matches is being played in Edinburgh for the first time after two years in Cardiff.